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rabbit anti brca1 polyclonal antibody  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology rabbit anti brca1 polyclonal antibody
    Rabbit Anti Brca1 Polyclonal Antibody, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 707 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rabbit anti brca1 polyclonal antibody/product/Santa Cruz Biotechnology
    Average 96 stars, based on 707 article reviews
    rabbit anti brca1 polyclonal antibody - by Bioz Stars, 2026-02
    96/100 stars

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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker <t>BRCA1,</t> and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.
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    NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker BRCA1, and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.

    Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    Article Title: Acid Sphingomyelinase-Ceramide Induced Vascular Injury Determines Colorectal Cancer Stem Cell Fate

    doi: 10.33594/000000562

    Figure Lengend Snippet: NSG mice harboring CLR27-2 PDXs were treated with DC101 (1.6mg/25 gm mouse) at 1h before 40 Gy SDRT and sacrificed at the indicated times thereafter. (A, C, E) Representative fluorescent images of DNA repair foci obtained from tumors stained for the DSB marker gH2AX, the HRR marker BRCA1, and the NHEJ marker DNA- PKcs at 2h post radiation (40× magnification). (B, D, F). Selective reduction in HRR sensitizes radioresistant CLR27-2, but not radiosensitive CLR1-1 CRC PDXs. Data (mean ± SEM) are collated from 6 representative screenshots derived from 2–4 mice per group.

    Article Snippet: Primary antibodies used to stain DNA repair proteins are as follows: mouse monoclonal anti-γH2AX-phosphoSer139 (Milli-pore [clone JBW301] 05–636; dilution 1:1000), rabbit polyclonal anti-BRCA1 (Ser1387) (Novus Biologicals, NB100–225SS; dilution 1:250), and mouse monoclonal anti-DNA-PKcs (phospho-Thr2609) (Abcam, ab18356; dilution 1:250).

    Techniques: Staining, Marker, Derivative Assay